Applied Biomechanics and Bioinformatics for Analysis of Limb Lengthening Research

Biomechanics demonstrated by the variety of topics associated with physical therapy such as exercise, sports, neuromuscular control, energetics, and locomotor apparatus. Biomechanical treatment related to physical and mechanical components of the patient. Physical therapists are educated in the bio aspect of treatment, whereas prosthetists/orthotists are educated in the mechanical aspect. Physical therapy need to become more familiar with mechanical treatment and learn how to integrate this into their physical treatment program. Orthotics must become more familiar with the importance of physical treatment and the internal corrective forces necessary for efficient ambulation. In order to develop biomechanical treatment, an understanding of genetic factors that based on responsible genes for bone formation, is needed. Limb lengthening is used increasingly for children who have unequal lengths. It is critical for maintenance of joint motion that can be difficult to achieve. The National Institute for Health and Care Excellence (NICE) recommends human growth hormone treatment (HGH) as an option for children whose is associated with poor growth. Also, it can sometimes help prevent problems such as weak bones (osteoporosis). Recently, HGH can reduce muscle damage during limb lengthening by enhancing myogenesis and decreasing fibrogenesis. Improved limb-lengthening strategies in terms of tissue engineering and gene therapy, or enhancement of bone repair, are under intense investigation. This article illustrates how bioinformatics and physical therapy can improve a patient's status by assistance of biomechanical treatment.